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Pharmacology: Pharmacodynamics: Mode or Mechanisms of Action: Antipsychotic: Thought to improve psychotic conditions by blocking postsynaptic dopamine receptors in the brain. They also produce an alpha-adrenergic blocking effect and depress the release of hypothalamic, pituitary and hypophyseal hormones.
Pharmacokinetics: Protein Binding: very high; Biotransformation: Hepatic.
Onset of action: Gradual (up to several weeks) and variable between patients.
Time to peak effect: Approximately 4 to 7 days to achieve steady-state plasma concentration;
Peak therapeutic effects may take from 6 weeks to 6 months.
Elimination: Primarily renal, biliary.
